Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Enamel nanocrystal misorientation increased with meat-eating and agriculture.

Nature·2026

Same author

Chromium-for-Aluminum Substitution in Synthetic Serpentine.

Nanomaterials (Basel, Switzerland)·2026

Same author

Pyrite (001) Interface Chemistry is Controlled by a Sulfoxy Termination.

Langmuir : the ACS journal of surfaces and colloids·2026

Same author

Depth of nutrient uptake by deep-rooted plants is regulated by water availability.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Vector diversity and malaria prevalence: global trends and local determinants.

Proceedings. Biological sciences·2025

Same author

Experimentally enhancing dispersal reveals the outsized importance of transient dynamics in a fluctuating environment.

Proceedings of the National Academy of Sciences of the United States of America·2025

Search research articles

Related Experiment Video

Updated: May 5, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

OpenSlide: A vendor-neutral software foundation for digital pathology.

Adam Goode¹, Benjamin Gilbert, Jan Harkes

¹School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States ; Google, Pittsburgh, PA, USA.

Journal of Pathology Informatics

|November 19, 2013

Summary

Digital slides offer pathology advancements but face data challenges. OpenSlide is a vendor-neutral library enabling seamless handling of diverse digital slide formats, improving interoperability for researchers.

Keywords:

Diamond OpenDiamond PathFind digital imaging and communications in medicine digital slide scanner whole-slide image

More Related Videos

Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells

Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells

Published on: October 13, 2023

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

Related Experiment Videos

Last Updated: May 5, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells

Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells

Published on: October 13, 2023

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

Area of Science:

Digital Pathology
Computational Pathology
Medical Informatics

Background:

Digital slides are emerging as a replacement for traditional glass slides in pathology.
Significant challenges exist in data storage, transmission, processing, and interoperability of digital slides.
Proprietary data formats from different vendors hinder widespread adoption and data sharing.

Purpose of the Study:

To present the design and implementation of OpenSlide, a vendor-neutral library.
To address the interoperability issues caused by diverse digital slide formats.
To facilitate the use of digital slides in pathology research and practice.

Main Methods:

Development of a C library named OpenSlide.
Implementation of vendor-neutral data format reading and manipulation capabilities.
Design for extensibility and interfacing with various programming languages.

Main Results:

OpenSlide provides a unified interface for diverse digital slide formats.
Applications using OpenSlide can transparently handle multiple vendor formats.
The library is extensible and supports various programming languages.

Conclusions:

OpenSlide effectively overcomes vendor-specific data format challenges in digital pathology.
The library enhances interoperability, benefiting pathologists and researchers.
OpenSlide is widely adopted by academic and industrial organizations globally.