Related Experiment Video
Updated: May 5, 2026

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor CAR T Cell Infusions in Mice
Published on: February 24, 2023
Combining cellular and gene therapy approaches for treatment of intracranial tumors
Michelle J Hickey1, Noriyuki Kasahara, Barbara M Mueller
1Department of Neurosurgery; University of California Los Angeles; Los Angeles, CA USA.
Abstract:
New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.
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