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[Growth and body composition changes in late preterm infants in the first months of life]
N Liotto1, F Garbarino, E Garavaglia
1Neonatal Intensive Care Unit (NICU), Department of Clinical Science and Comunity Health, Fondazione IRCCS "Ca' Granda" Ospedale Maggiore Policlinico, University of Milan, Via Commenda 12, 20122 Milan, Italy. nadia.liotto@unimi.it
Insights
Late preterm infants show rapid fat mass gain, reaching levels similar to very low birth weight infants by 3 months corrected age. This catch-up fat may influence future chronic disease risk.
Area of Science:
- Neonatal physiology and growth
- Pediatric nutrition and body composition
Context:
- Late preterm infants (34-36 weeks gestation) have distinct growth trajectories compared to extremely preterm and full-term infants.
- Understanding early body composition is crucial for assessing long-term health outcomes in preterm populations.
Purpose:
- To compare the growth and body composition of late preterm infants with extremely preterm and full-term infants.
- To analyze anthropometric parameters and body composition changes from birth to 3 months corrected age.
Summary:
- Late preterm infants exhibited higher weight, length, and head circumference than very low birth weight infants but lower fat mass early on.
- A rapid increase in fat mass was observed in late preterm infants between the fifth day of life and term corrected age, reaching levels comparable to very low birth weight infants by 3 months corrected age.
- Preterm infants showed higher fat mass percentage in the first month corrected age compared to full-term infants, a difference that diminished by 3 months corrected age.
Impact:
- Findings highlight the dynamic nature of body composition changes in late preterm infants.
- The rapid fat accumulation warrants further investigation into its potential long-term health implications, including the risk of chronic diseases.
Objectives:
The aim of this study was to compare growth and body composition of late preterm infants to that of extremely preterm and full-term infants.
Methods:
Observational longitudinal study. Forty-nine late preterm infants and 63 extremely preterm infants were included in the study. Forty healthy, full-term, breast-fed infants were enrolled as a reference group. Anthropometric parameters and body composition by an air displacement plethysmography system were assessed at 36th week, at term, at 1 and 3 months of corrected age in all groups. Late preterm infants were also assessed on the fifth day of life.
Results:
Late preterm infants showed higher weight, length and head circumference values than those of very low birth weight infants but lower fat mass values on the fifth day of life and at 36th week of corrected age. However, at 3 months of corrected age, percentage of fat mass in late preterm infants reached values comparable with those of very low birth weight infants, probably because of the fast catch-up fat recorded between the fifth day of life and term corrected age. Moreover, percentage of fat mass in the first month of corrected age in preterm infants was higher as compared with full-term infants. This difference was no longer found at 3 months of corrected age.
Conclusions:
Further studies are needed to investigate whether this rapid increase in fat mass may modulate the risk of chronic diseases.
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