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Updated: May 5, 2026

Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins
Published on: May 22, 2017
Chiroptical control in helical receptor-anion complexes
Hiromitsu Maeda1, Tomohiro Shirai, Yuya Bando
1College of Pharmaceutical Sciences, Ritsumeikan University , Kusatsu 525-8577, Japan, Advanced Elements Chemistry Research Team and Elements Chemistry Laboratory, RIKEN , Wako 351-0198, Japan, Faculty of Science and Technology, Seikei University , Musashino 180-8633, Japan, Graduate School of Pharmaceutical Sciences, The University of Tokyo , Tokyo 113-0033, Japan, PRESTO, Japan Science and Technology Agency (JST), Kawaguchi 332-0012, Japan, Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST) , Ikoma 630-0192, Japan, and National Institute for Materials Science (NIMS) , Tsukuba 305-0044, Japan.
Abstract:
Dimers of appropriately arranged anion-responsive π-conjugated moieties form helical structures by interaction with chiral anions. Terphenyl-bridged dimers of dipyrrolyldiketone boron complexes show chirality induced by binding l-amino acid anions, as observed by circular dichroism (CD) and circularly polarized luminescence (CPL). The preferred configurations of helical structures depend on the geometries of the terphenyl spacer moieties.
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