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Updated: May 5, 2026
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
[Streptococcus agalactiae late-onset neonatal infections in Barcelona (1996-2010)]
Teresa Juncosa-Morros1, Cèlia Guardià-Llobet2, Jordi Bosch-Mestres3
1Servicio de Microbiología, Hospital Universitari Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
Insights
Group B Streptococcus (GBS) late-onset disease incidence remains unchanged despite prevention efforts. Increased risk observed over 15 years highlights the need for continued vigilance against GBS infections in newborns.
Area of Science:
- Neonatal infections
- Bacterial pathogenesis
- Public health surveillance
Background:
- Group B Streptococcus (GBS) is a leading cause of neonatal infections.
- Late-onset GBS disease (after 7 days of life) presents distinct challenges.
- Understanding GBS evolution is crucial for effective prevention strategies.
Purpose of the Study:
- To characterize group B Streptococcus (GBS) late-onset diseases over 15 years.
- To analyze the impact of prophylactic measures on early-onset GBS infections.
- To assess trends in GBS late-onset disease incidence and risk factors.
Main Methods:
- Retrospective review of 143 late-onset GBS cases (1996-2010).
- Analysis of incidence rates, clinical presentations, and maternal/obstetric factors.
- Evaluation of GBS serotypes and mortality.
Main Results:
- Overall incidence of GBS late-onset disease was 0.42 per 1000 live births.
- Sepsis/bacteremia (63.6%) and meningitis (32.8%) were common presentations.
- Despite prophylaxis, incidence showed a slight increasing trend, with serotypes III and Ia predominant.
Conclusions:
- GBS late-onset disease incidence has not decreased despite early-onset prevention practices.
- The persistent risk necessitates ongoing awareness and management strategies.
- Further research into GBS prevention and treatment is warranted.
Objetive:
To study the characteristics and evolution of group B Streptococcus (GBS) late-onset diseases, over a period of 15years in 8hospitals the Barcelona area and analyze the possible impact of prophylactic measures for the prevention of early-onset neonatal infections.
Methods:
Retrospective review of all patients diagnosed with late-onset neonatal disease due to GBS from 1996 to 2010.
Results:
A total of 143 patients were diagnosed. Of these, 51 were born in others hospitals. The overalll incidence was 0.42 per 1000 live births, varying between 0.14‰ in the year 2000 and 0.80‰ in 2009. A slight but sustained tendency of increased risk was observed over the years, 6.9% in the overall disease (with no statistical significance). Sepsis/bacteremia was detected in 63.6% of the newborns, meningitis in 32.8%, and arthritis/osteomyelitis in 3.5%. In cases with known obstetrics dates, 53% of mothers had been colonized by GBS during pregnancy, 53.8% received intrapartum antibiotic prophylaxis, and 41.2% had some obstetric risk factors, particularly premature birth in 35.9%. There was a 2.8% mortality rate in the neonates, and predominant serotypes were III and Ia.
Conclusions:
The incidence of GBS late-onset disease has not decreased despite the control practices of early-onset disease, and possibility of this appearing must be taken into account.
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