Related Experiment Video
Updated: May 5, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
Published on: September 28, 2015
Angioedema from recombinant TPA administration: case report and pathophysiology review
Alison Foster-Goldman1, Danielle McCarthy
1Department of Emergency Medicine, Northwestern University, Chicago, IL.
Abstract:
Angioedema is an uncommon, yet morbid, adverse reaction to recombinant tissue plasminogen activator (rtPA) administration for ischemic stroke. Orolingual edema may preclude completion of rtPA therapy and cause potential airway compromise. Few case reports and case series have examined the incidence of angioedema and anaphylaxis related to this common stroke therapy. We report a case of orolingual edema and bleeding in a patient who received rtPA for acute ischemic stroke who was concurrently on an angiotension-converting enzyme inhibitor and discuss the pathophysiology of this reaction.
Related Concept Videos
Cytotoxic Edema: Pathophysiology
Cerebral Edema ll: Pathophysiology
Acute Inflammation II: Local and Systemic Effects
Aortic Regurgitation I: Introduction
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Peripheral Artery Disease V: Postoperative Nursing Management

