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Current and novel bronchodilators in respiratory disease
1Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, School of Biomedical Science, King's College London, London, UK.
Current Opinion in Pulmonary Medicine
|November 20, 2013
Summary
Long-acting beta2-agonists and muscarinic antagonists offer sustained bronchodilation for asthma and COPD. Research continues into novel targets and drug development for improved respiratory treatments.
Area of Science:
- Pulmonary Medicine
- Pharmacology
- Respiratory Diseases
Background:
- Beta2-agonists and muscarinic antagonists are mainstays in treating asthma and COPD.
- Novel drug targets are under investigation for improved bronchodilator therapies.
Purpose of the Study:
- To review current developments in bronchodilator drug discovery and clinical utility.
- To summarize advances in targeting pathways for respiratory diseases.
Main Methods:
- Literature review of recent clinical studies and pharmacological research.
- Analysis of novel drug targets and their therapeutic potential.
Main Results:
- Once-daily inhaled long-acting beta2-agonists and muscarinic antagonists provide sustained bronchodilation.
- Novel targets like TAS2R and PDE3/4 inhibitors show clinical effectiveness.
- Combination therapies offer benefits over monotherapy.
Conclusions:
- Inhaled long-acting beta2-agonists and muscarinic antagonists remain primary maintenance bronchodilators.
- Ongoing research into novel targets (e.g., PDE3/4, TAS2R) and biased agonists fuels new bronchodilator development.
- Combination therapies and new drug targets offer enhanced benefits for asthma and COPD management.
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