Related Experiment Video
Updated: Sep 14, 2026

The Tail Suspension Test
Published on: January 28, 2012
Time-related response of central serotonergic function to lithium administration
Abstract:
The possibility of "acute" (1 hr) changes in serotonergic function by lithium chloride (LiCl) administration was investigated in the rat corpus striatum and frontal cerebral cortex: an increase in 5-HT biosynthesis in vivo and 5-HIAA levels was observed in both areas. After chronic LiCl treatment (14 days) only cortical 5-HIAA levels were reduced. These changes were not correlated with plasma lithium levels. Consequently, LiCl "acutely" (1 hr) probably enhances striatal and cortical serotonergic transmission, this response varying with time of treatment as a result of possible neuronal compensatory mechanisms.
More Related Videos
07:02A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
09:12Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
Published on: March 17, 2019
Related Concept Videos
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Mania and Antimanic Drugs: Overview
Antidepressant Drugs: MAOIs and Other Agents
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...