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Related Concept Videos

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Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
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Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
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Estimating functional connectivity in an electrically coupled interneuron network.

Pepe Alcami1, Alain Marty

  • 1Laboratoire de Physiologie Cérébrale, Centre National de la Recherche Scientifique and Université Paris Descartes, 75006 Paris, France.

Proceedings of the National Academy of Sciences of the United States of America
|November 20, 2013
PubMed
Summary
This summary is machine-generated.

Electrical coupling in the brain

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Area of Science:

  • Neuroscience
  • Cellular Electrophysiology
  • Computational Neuroscience

Background:

  • Electrical coupling via gap junctions is known in mammalian brain areas.
  • Quantitative descriptions of interneuron network connectivity and its impact on cellular properties are lacking.
  • Previous methods struggle to differentiate direct from indirect cellular connections.

Purpose of the Study:

  • To quantitatively describe network electrical connectivity in cerebellar molecular layer interneurons.
  • To assess the impact of electrical coupling on cellular passive properties.
  • To differentiate direct and indirect synaptic connections.

Main Methods:

  • Analysis of capacitive currents under voltage clamp in rodent molecular layer interneurons.
  • Dual cell recordings of electrical synapses.
  • Modeling of electrical coupling and its effect on voltage spread.

Main Results:

  • An exponential component in capacitive currents (~20 ms time constant) indicates capacitive loading through gap junctions.
  • Estimated ~4 direct neighbors for rat basket cells and ~1 for rat stellate cells.
  • Weighted neighbor numbers: 1.69 for basket cells, 0.23 for stellate cells, indicating differential voltage spread.

Conclusions:

  • Developed effective tools for analyzing electrically coupled interneuron networks.
  • Electrical communication is stronger between basket cells than stellate cells in juvenile rodents.
  • Gap junction contribution to cellular input conductance was estimated.