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Automated Analysis of Dynamic Ca2+ Signals in Image Sequences

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Acquisition and quantification of ion images with a camera-based detection system and classical quantification

F Michiels¹, W Vanhoolst, P Van Espen

¹Department of Chemistry, University of Antwerp (U.I.A.), Universiteitsplein 1, B-2610, Wihijk, Belgium.

Journal of the American Society for Mass Spectrometry

|November 20, 2013

Summary

This study details a camera-based detection system for secondary ion microscopy, enabling quantitative analysis of ion images. The methods were validated using steel and aluminum reference materials for accurate elemental composition.

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Area of Science:

Materials Science
Analytical Chemistry
Microscopy

Background:

Secondary ion mass spectrometry (SIMS) is crucial for elemental analysis.
Quantitative analysis in SIMS can be challenging due to complex matrix effects and detector limitations.

Purpose of the Study:

To investigate the quantitative analytical characteristics of a camera-based detection system for SIMS.
To evaluate methods for quantifying ion images with large dynamic ranges.

Main Methods:

Utilized a camera-based detection system for secondary ion microscopy.
Acquired ion images through multiple exposures to achieve large dynamic ranges.
Applied the sensitivity factor method and the matrix ion species ratio method for quantification.

Main Results:

The camera-based system demonstrated quantitative analytical capabilities.
Successful quantification of ion images was achieved using the described methods.
Analysis of steel and aluminum standard reference materials validated the system's performance.

Conclusions:

The camera-based detection system is suitable for quantitative analysis in SIMS.
The employed quantification methods are effective for analyzing complex materials like steel and aluminum.