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Updated: May 5, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

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Efinaconazole: first global approval.

Trina Patel¹, Sohita Dhillon

¹Adis R & D Insight, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore, 0754, Auckland, New Zealand, dru@adis.com.

|November 20, 2013

Summary

This summary is machine-generated.

Efinaconazole, a topical antifungal, gained its first global approval for treating onychomycosis in 2013. This triazole compound inhibits ergosterol synthesis, offering a new option for fungal nail infections.

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Area of Science:

Dermatology
Mycology
Pharmaceutical Development

Background:

Onychomycosis is a common fungal nail infection.
Topical treatments are sought for improved efficacy and safety.
Efinaconazole is a novel topical triazole antifungal.

Purpose of the Study:

To summarize the development milestones of efinaconazole.
To report the first global approval of efinaconazole for onychomycosis.

Main Methods:

Review of efinaconazole's development and regulatory status.
Description of efinaconazole's proposed mechanism of action.

Main Results:

Efinaconazole 10% topical solution received first global approval in Canada in October 2013.
Regulatory reviews are ongoing in the US and Japan.

Conclusions:

Efinaconazole represents a significant development in topical antifungal therapy.
The drug's approval marks a milestone in treating onychomycosis.