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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Related Experiment Video

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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Bullous systemic lupus erythematosus.

Chander Grover1, Ananta Khurana, Sonal Sharma

  • 1Department of Dermatology, University College of Medical Sciences, Dilshad Garden, Delhi, India.

Indian Journal of Dermatology
|November 20, 2013
PubMed
Summary

Bullous Systemic Lupus Erythematosus (BSLE) is a rare skin condition. This case study highlights its diagnosis and successful treatment with dapsone.

Area of Science:

  • Dermatology
  • Rheumatology
  • Immunology

Background:

  • Bullous Systemic Lupus Erythematosus (BSLE) is a rare variant of Systemic Lupus Erythematosus (SLE).
  • Histologically, it presents with subepidermal bullae and a neutrophilic infiltrate.
  • Immune deposition of immunoglobulins and C3 at the basement membrane zone is characteristic, often with antibodies against type VII collagen.

Purpose of the Study:

  • To report a case of BSLE.
  • To emphasize the diagnostic criteria and management of BSLE.
  • To highlight the efficacy of dapsone in treating BSLE.

Main Methods:

  • Clinical presentation of a 39-year-old female with extensive vesicobullous eruption.
  • Laboratory findings including photosensitivity, anemia, and high antibody titers confirming SLE.
Keywords:
Dapsoneimmunobullous diseasestype VII collagen

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  • Histopathological and direct immunofluorescence studies to diagnose BSLE.

    • Main Results:

    • The patient presented with widespread blistering lesions and systemic SLE features.
    • Histopathology and immunofluorescence confirmed BSLE.
    • The patient showed a favorable response to dapsone therapy.

    Conclusions:

    • BSLE requires differentiation from other subepidermal bullous diseases due to potential SLE manifestations.
    • Clinical and histopathological findings are crucial for diagnosing BSLE.
    • Dapsone is an effective treatment option for BSLE, as demonstrated in this case.