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Related Experiment Video

Updated: May 5, 2026

Formation of Dispersible Taohong Siwu Tablets
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Floating matrix tablets of domperidone formulation and optimization using simplex lattice design.

Shailesh Prajapati1, Laxmanbhai Patel, Chhaganbhai Patel

  • 1Department of Pharmaceutics, Shri Sarvajanik Pharmacy College, Mehsana, Gujarat, India.

Iranian Journal of Pharmaceutical Research : IJPR
|November 20, 2013
PubMed
Summary

This study optimized domperidone floating matrix tablets using polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC). Formulation adjustments, particularly PEO content and sodium bicarbonate concentration, effectively controlled drug release for stable, effective delivery.

Keywords:
DomperidoneFloating lag timeFloating matrix tabletsHydroxypropyl methylcellulosePolyethylene oxideRelease kineticsSimplex lattice designTotal floating time.

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Floating matrix tablets offer prolonged drug release and improved bioavailability.
  • Domperidone is a widely used antiemetic and prokinetic agent.
  • Hydrophilic polymers like PEO and HPMC are key in designing controlled-release formulations.

Purpose of the Study:

  • To develop and optimize a floating matrix tablet formulation for domperidone.
  • To investigate the influence of polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) on drug release kinetics.
  • To achieve a desired drug release profile using a simplex lattice design.

Main Methods:

  • Preparation of domperidone floating matrix tablets using PEO and HPMC.
  • Application of a simplex lattice design to optimize formulation variables.
  • Evaluation of dependent variables including floating lag time, drug release (t50, t80), diffusion coefficient (n), and release rate (k).
  • Analysis of drug release kinetics using the Korsmeyer-Peppas model.

Main Results:

  • Both PEO and HPMC significantly influenced the drug release profile.
  • Polyethylene oxide (PEO) content was identified as the primary factor controlling drug release.
  • Sodium bicarbonate concentration allowed for tailoring of drug release from hydrophilic matrices.
  • Formulations demonstrated good stability for 3 months under accelerated conditions (40°C / 75% RH).
  • Drug release predominantly followed the Korsmeyer-Peppas model, indicating diffusion-controlled release.

Conclusions:

  • Optimized floating matrix tablets containing domperidone can be successfully prepared using PEO and HPMC.
  • The drug release rate is controllable by adjusting PEO concentration and sodium bicarbonate levels.
  • The developed formulations exhibit favorable stability and release characteristics for potential therapeutic applications.