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Updated: May 5, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
Chemokine-enhanced DNA vaccination in cancer immunotherapy
Olga Igoucheva1, Rebecca Jonas, Vitali Alexeev
1Department of Dermatology and Cutaneous Biology; Jefferson Medical College; Thomas Jefferson University; Philadelphia, PA USA.
Abstract:
We have demonstrated that priming of intratumoral and intradermal vaccination sites with chemokines enhances cytotoxic immune response against established neoplasms. Additional insights into the molecular mechanisms that underlie these findings and the optimization of such an approach may lead to the development of cost-effective and generic immunotherapeutic regimens against cancer.
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