Related Experiment Video
Updated: May 5, 2026
05:32
Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
Published on: August 11, 2023
3.2K
Transient central diabetes insipidus following ischemic stroke
Muthukrishnan Jayaraman1, Sandeep Kumar, F M H Ahmad
1Department of Medicine, Command Hoapital (Western Command), Chandimandir, Panchkula, Haryana, India.
Indian Journal of Endocrinology and Metabolism
|November 20, 2013
Summary
Central Diabetes Insipidus (CDI) is a rare complication of brain infarction. This case highlights transient CDI in a young male following high-altitude ischemic brain injury, resolving with recovery.
Area of Science:
- Neurology
- Endocrinology
Background:
- Central Diabetes Insipidus (CDI) is infrequently associated with ischemic brain infarction.
- Posterior pituitary ischemia is a potential cause of idiopathic CDI.
Observation:
- A young male presented with bilateral extensive ischemic infarction after high-altitude exposure.
- The patient experienced transient polyuria, indicative of central diabetes insipidus.
Findings:
- The patient required desmopressin therapy for the induced central diabetes insipidus.
- Diabetes insipidus resolved completely as neurological recovery progressed.
Implications:
- This case supports the link between brain ischemia and central diabetes insipidus.
- Transient DI may occur following hypoxic-ischemic brain injury, particularly at high altitudes.
- Resolution of DI with neurological recovery suggests a potentially reversible pituitary or hypothalamic insult.
Related Concept Videos
01:26Transient Ischemic Attack l: Introduction
34
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
34
01:29Diabetes Insipidus I: Introduction
65
Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...
65
01:22Diabetes Insipidus II: Pathophysiology
36
Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...
36
01:15Ischemic Stroke ll: Pathophysiology
68
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
68
01:15Ischemic Stroke l: Introduction
53
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
53
01:29Stroke: Introduction and Types
69
A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
69