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Does Raised Transaminases Predict Severity and Mortality in Patients with COVID 19?
Padmaprakash Kodavoor Vadiraj1, Sandeep Thareja1, Nishant Raman1
1Department of Medicine, Base Hospital, Delhi Cantt, New Delhi, 110010, India.
Journal of Clinical and Experimental Hepatology
|February 7, 2022
Summary
COVID-19 impacts the liver, with elevated AST and low albumin predicting severe disease and mortality. These liver function tests aid in managing and predicting COVID-19 outcomes.
Area of Science:
- Hepatology
- Infectious Diseases
- Internal Medicine
Background:
- Coronavirus Disease 2019 (COVID-19) is a multisystem disorder with significant hepatic involvement.
- Clinical implications and effects of COVID-19 on liver function, morbidity, and mortality are still emerging.
Purpose of the Study:
- To investigate hepatic involvement in hospitalized COVID-19 patients.
- To analyze alterations in liver function tests and their significance in disease outcome.
Main Methods:
- Retrospective cohort study of 708 hospitalized COVID-19 patients (aged ≥15) in Northern India.
- Analysis of liver function tests (bilirubin, AST, ALT, albumin) and their association with disease severity and 28-day mortality.
- Statistical analysis included regression and survival analysis.
Main Results:
- Elevated AST (69.91%) and ALT (80.22%) were common. AST and ALT levels correlated with moderate/severe COVID-19.
- Low serum albumin was significantly associated with increased odds of moderate/severe disease.
- Elevated AST and low serum albumin were significant predictors of 28-day mortality.
Conclusions:
- Liver function abnormalities are frequent in COVID-19 patients.
- AST and serum albumin levels are valuable predictors of COVID-19 severity and mortality.
- These markers can aid in the management and prognostication of COVID-19.
Keywords:
ACG, American College of GastroenterologyALC, Absolute Lymphocyte CountALP, Alkaline PhosphataseALT, Alanine Aminotransferase/Alanine TransaminaseANC, Absolute Neutrophil CountAST, Aspartate Aminotransferase/Aspartate TransaminaseAUC, Area Under the CurveCOVID-19COVID-19, Coronavirus Disease 2019CRP, C Reactive ProteinGGT, Gamma Glutamyl TransferaseHb, HemoglobinIQR, Interquartile RangeNLR, Neutrophil to Lymphocyte RatioOR, Odds RatioPLT, PlateletPT, Prothrombin TimeROC, Receiver Operating characteristic CurveRT PCR, Real Time Transcription Polymerase chain reactionSpO2, Saturation of oxygen by pulse oximetryTLC, Total Leukocyte CountULN, Upper Limit of Normalliver functionsmortalityserum albuminsevere diseaseMore Related Videos
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