An unusual cause of progressive quadriparesis

Area of Science:

• Oncology
• Neurology
• Spinal Surgery

Background:

• Thyroid carcinoma is an uncommon cause of compressive myelopathy.
• Quadriparesis as the initial presentation of follicular thyroid carcinoma is rare.
• Malignancies affecting the craniovertebral junction can lead to significant neurological deficits.

Observation:

• A 55-year-old woman presented with a two-month history of progressive quadriparesis.
• Imaging revealed a large tumor at the craniovertebral junction, destroying C1 and C2 vertebrae.
• Histopathological examination confirmed follicular thyroid carcinoma.

Findings:

• Follicular thyroid carcinoma can present with severe neurological symptoms, including quadriparesis.
• Surgical excision and spinal stabilization are feasible for craniovertebral junction tumors.
• Multimodal treatment including radiotherapy can be effective in managing thyroid carcinoma with spinal involvement.

Implications:

• This case expands the understanding of rare presentations of thyroid carcinoma.
• Highlights the importance of considering uncommon etiologies for compressive myelopathy.
• Emphasizes the role of a multidisciplinary approach in managing complex spinal tumors.