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Related Experiment Videos

Spontaneous hepatocellular carcinomas in lungfish.

P Masahito, T Ishikawa, H Sugano

    Journal of the National Cancer Institute
    |July 1, 1986
    PubMed
    Summary

    Lungfish, including South American and African species, developed liver tumors during a 2-5 year observation period in Japan. These findings suggest lungfish may be predisposed to liver tumor development.

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    Applied biochemistry and biotechnology·2013

    Area of Science:

    • Comparative Pathology
    • Aquatic Animal Health
    • Neoplastic Disease Research

    Background:

    • Lungfish (Lepidosiren paradoxa and Protopterus amphibius) are ancient freshwater fish with unique biological characteristics.
    • Understanding diseases in diverse aquatic species is crucial for conservation and veterinary science.
    • Previous research on lungfish neoplasms is limited.

    Observation:

    • Liver tumors were identified in three lungfish (two South American, one African) housed in Japanese aquariums for 2-5 years.
    • Tumor presentation varied, including large external swellings and incidental autopsy findings.
    • Histological analysis revealed diverse tumor types, predominantly trabecular hepatomas, with some exhibiting glandular, papillary, or poorly differentiated hepatocellular carcinoma features.

    Findings:

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    • A high incidence of liver tumors (3/14 autopsied cases across 6 species) was noted in the studied lungfish population.
    • Tumor morphology displayed significant variation, even within individual fish.
    • The etiology of these lungfish liver tumors remains undetermined.

    Implications:

    • Lungfish may possess an inherent susceptibility to developing liver tumors.
    • Further research is warranted to investigate the causes and mechanisms of tumorigenesis in lungfish.
    • These findings contribute to the broader understanding of neoplasia in non-mammalian vertebrates.