Related Experiment Video
Updated: May 5, 2026
07:27
A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
Published on: May 16, 2013
21.1K
Congenital malaria with atypical presentation in a preterm neonate
1Department of Pediatrics, Katihar Medical College and Hospital, Katihar, Bihar, India.
Journal of Clinical Neonatology
|November 20, 2013
Summary
Congenital malaria (CM) is rare, typically causing fever, jaundice, and anemia. This case highlights a unique presentation of CM without fever, despite other classic symptoms.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neonatal Health
Background:
- Congenital malaria (CM) is an uncommon parasitic infection transmitted from mother to child during pregnancy or delivery.
- Fever is a hallmark symptom of CM, often accompanied by jaundice, anemia, and hepatosplenomegaly.
- Fewer than 300 cases of CM have been documented globally, underscoring its rarity.
Observation:
- A neonate presented with clinical manifestations consistent with congenital malaria.
- The infant exhibited jaundice, anemia, and hepatosplenomegaly, which are typical signs of CM.
- Notably, the infant did not present with fever, an atypical clinical feature for CM.
Findings:
- This case represents a rare instance of congenital malaria presenting without fever.
- The presence of typical CM symptoms (jaundice, anemia, hepatosplenomegaly) in the absence of fever challenges conventional diagnostic criteria.
- Diagnostic confirmation relied on identifying Plasmodium parasites in the infant's blood.
Implications:
- Physicians should consider congenital malaria in neonates with typical CM signs, even without fever.
- This case broadens the clinical spectrum of congenital malaria, aiding in earlier diagnosis and treatment.
- Increased awareness of atypical CM presentations is crucial for improving infant outcomes and reducing morbidity.
More Related Videos
Related Concept Videos
01:22Bacterial Meningitis I: Introduction
31
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
31
01:14Atypical Pneumonia
88
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
88
01:27Cytomegalovirus Disease
108
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
108
01:19Encephalitis l: Introduction
27
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
27
00:58Symbiosis
27.8K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
27.8K
01:20Inborn Errors of Metabolism
1.1K
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
1.1K