Protective role of melatonin in liver damage
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Updated: May 5, 2026

A Simple and Efficient Method for In Vivo Cardiac-specific Gene Manipulation by Intramyocardial Injection in Mice
Published on: April 16, 2018
Cezary Chojnacki, Ewa Walecka-Kapica, Marek Romanowski
1Department of Gastroenterology, Medical University of Lodz, 1 Haller's Square, 90-647 Lodz, Poland. gastrologia@umed.lodz.pl.
Abstract:
The liver plays a key role in the detoxification of numerous molecules which results in the formation of an excessive number of toxic reactive oxygen species. This results in oxidative damage to the hepatocytes, which when severe, compromises the function of this critical organ. A variety of antioxidants protect the liver from free radical-mediated damage, one of the best of which is melatonin. Clinical studies have confirmed the melatonin, as well as it precursor tryptophan, protect the liver from non-alcoholic liver disease and also during the surgical procedure of partial liver resection.
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