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Ecklonia cava promotes hair growth.

S S Bak1, B N Ahn, J A Kim

  • 1Marine Bioprocess Research Center, Pukyong National University, Busan, Korea.

Clinical and Experimental Dermatology
|November 21, 2013
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Summary

The marine seaweed Ecklonia cava and its component dioxinodehydroeckol promote hair growth by stimulating dermal papilla cells and outer root sheath cells. This study investigated their effects on hair shaft elongation and the hair cycle in vitro and in vivo.

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Area of Science:

  • Marine biology
  • Dermatology
  • Cosmetic science

Background:

  • Edible marine seaweed Ecklonia cava is known for protective effects on skin elasticity.
  • Its mechanisms involve regulation of antioxidative and anti-inflammatory responses.

Purpose of the Study:

  • To evaluate the effect of Ecklonia cava and its component dioxinodehydroeckol on hair-shaft growth.
  • To assess hair growth promotion in cultured human hair follicles and in mice models.

Main Methods:

  • Cell viability assays (MTT) for human dermal papilla cells (DPCs) and outer root sheath (ORS) cells.
  • In vitro hair-follicle organ-culture system for hair-shaft growth measurement.
  • In vivo study on C57BL/6 mice to examine anagen induction and Insulin-like Growth Factor-1 (IGF-1) expression.

Main Results:

  • The ethyl acetate-soluble fraction of E. cava (EAFE) significantly increased proliferation in DPCs and ORS cells.
  • EAFE and dioxinodehydroeckol promoted hair shaft elongation and induced the transition from telogen to anagen phase in mice.
  • Both EAFE and dioxinodehydroeckol increased IGF-1 expression in DPCs.

Conclusions:

  • Ecklonia cava, particularly its component dioxinodehydroeckol, stimulates hair growth.
  • The mechanism involves the promotion of DPCs and ORS cell activity and increased IGF-1 expression.