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Myxoid liposarcoma in a 91-year-old patient
Brandon S Sheffield1, Torsten O Nielsen
1Department of pathology and laboratory medicine, University of British Columbia, 899 West 12th Avenue, Vancouver, British Columbia V5Z 1M9, Canada. Brandon.s.Sheffield@gmail.com.
Molecular Cytogenetics
|November 21, 2013
Summary
Myxoid liposarcoma, typically seen in young adults, can occur in the elderly, as shown in a 91-year-old patient. Molecular assays confirm diagnosis in atypical cases.
Area of Science:
- Oncology
- Genetics
- Pathology
Background:
- Myxoid liposarcoma is a rare soft tissue sarcoma.
- It typically affects young adults and is characterized by a specific chromosomal rearrangement involving the DDIT3 locus.
Observation:
- A case of myxoid liposarcoma was diagnosed in a 91-year-old patient, the oldest on record.
- The patient presented with predominantly round cell histology on biopsy.
Findings:
- Fluorescence in situ hybridization (FISH) confirmed the pathognomonic chromosomal alteration at the DDIT3 and FUS loci.
- Reverse transcription polymerase chain reaction (RT-PCR) further supported the diagnosis.
Implications:
- This case expands the known age range for myxoid liposarcoma presentation.
- Molecular and cytogenetic analyses are crucial for diagnosing atypical presentations and confirming histology.
