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Updated: Jun 21, 2026
Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Previously unreported translocation (14;15)(q32; q11.2) observed in B-cell acute lymphoblastic leukemia: a case
Maliha Naz1, Jawad Hassan2,3, Neelum Mansoor1
1Department of Cytogenetics, Indus Hospital & Health Network, Karachi, Pakistan.
Abstract:
t(14;15) have rarely been seen in hematologic malignancies. Here we have reported a case of a 4-year-old male who presented with low grade fever and body aches and, was diagnosed on immunophenotyping as B-cell Acute Lymphoblastic Leukemia. Cytogenetic analysis demonstrated a previously unreported translocation t(14;15)(q32;q11.2). Fluorescent in situ hybridization (FISH) analysis on metaphases was also carried out to confirm the chromosomal aberration. To our knowledge, such a translocation has not been reported in hematological malignancy specifically in B-cell ALL.
