Related Experiment Video
Updated: May 5, 2026

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
[Guideline on Helicobacter pylori infection in children]
P E C Nel Mourad-Baars1, Angelika Kindermann, Leonie M A J Venmans
1LUMC, Willem-Alexander Kinderziekenhuis, Leiden.
Abstract:
In 2012, at the request of the Dutch Society of Paediatrics, a multidisciplinary working group developed a guideline entitled 'Helicobacter pylori infection in children aged 0-18 years'. The 2011 international guideline served as the guiding principle for this. The guideline includes recommendations on which children should be tested for H. pylori infection, the diagnostic tests to be used, the type of treatment to be given, and how follow-up should be conducted. Children can be tested and treated in both primary and secondary care. A gastroscopy is indicated if the presence of H. pylori in a child has been confirmed by a non-invasive test and two attempts at eradication have failed, and/or there are alarm symptoms that may point to the symptoms having a different underlying cause. A seven-day course of triple eradication therapy can be prescribed. As the level of resistance is low in the Netherlands, this therapy can be used in both the first and second instance without the pattern of resistance being known.
Related Concept Videos
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Peptic Ulcer
Gastritis II: Pathophysiology
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Peptic Ulcer Disease II: Pathophysiology
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.

