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Updated: May 5, 2026

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
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Evaluating an oncology systemic therapy computerized physician order entry system using international guidelines.

Sonal Gandhi1, Ivan Tyono, Mark Pasetka

  • 1Sunnybrook Odette Cancer Centre; and University of Toronto, Toronto, Ontario, Canada.

Journal of Oncology Practice
|November 21, 2013
PubMed
Summary

Computerized physician order entry (CPOE) systems improve chemotherapy safety by reducing medication errors. This review consolidates CPOE principles and evaluates an existing system, offering a framework for future oncology CPOE development.

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Area of Science:

  • Oncology
  • Health Informatics
  • Patient Safety

Background:

  • Chemotherapy administration is complex and susceptible to medication errors.
  • Computerized physician order entry (CPOE) is a key strategy for mitigating these errors and enhancing patient safety.
  • Cancer Care Ontario (CCO) developed the Oncology Patient Information System (OPIS) as a systemic therapy CPOE.

Purpose of the Study:

  • To review and consolidate principles for oncology CPOE systems from literature and international guidelines.
  • To evaluate the OPIS against established oncology CPOE standards.
  • To provide a framework for developing and evaluating CPOE platforms in oncology.

Main Methods:

  • Literature review of oncology CPOE principles.
  • Analysis of guidelines from the American Society of Clinical Oncology, Clinical Oncological Society of Australia, and CCO.
  • Evaluation of the OPIS against identified standards.

Main Results:

  • Consolidated principles for oncology CPOE systems were identified.
  • The OPIS was evaluated against these principles.
  • A working example of an oncology CPOE system was presented.

Conclusions:

  • Oncology CPOE systems are crucial for improving patient safety in chemotherapy.
  • The OPIS serves as a model for cancer CPOE development and evaluation.
  • Oncologists are key stakeholders in CPOE implementation and require informed decision-making.