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Updated: Feb 7, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Impact of partner bereavement on quality of cardiovascular disease management
Sunil M Shah1, Iain M Carey, Tess Harris
1Division of Population Health Sciences and Education, St. George's University of London, London, UK (S.M.S., I.M.C., T.H., S.de.W., D.G.C.); and School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex, London, UK (C.R.V.).
Insights
Bereavement increases cardiovascular risk due to lower quality of care. Maintaining cardiovascular disease management before and after loss is crucial for patient health.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Bereavement is a known risk factor for increased cardiovascular mortality.
- The specific impact of cardiovascular disease management quality during bereavement remains under-investigated.
Purpose of the Study:
- To investigate the association between partner bereavement and the quality of cardiovascular disease care in older adults.
- To determine if changes in routine care and medication prescribing around bereavement contribute to cardiovascular risk.
Main Methods:
- A UK primary-care database study matched 12,722 bereaved older adults with cardiovascular disease to 33,911 non-bereaved controls.
- Annual process measures of care and cardiovascular medication prescribing were analyzed in the year before and after bereavement.
- Odds ratios were calculated to compare changes in care quality between bereaved and non-bereaved groups.
Main Results:
- Uptake of annual cardiovascular care measures (cholesterol, blood pressure) was lower in the year preceding bereavement.
- A transient decrease in prescribing for lipid-lowering and antiplatelet medications was observed in the peri-bereavement period.
- Odds ratios indicated significantly poorer care measure uptake and medication coverage post-bereavement compared to controls.
Conclusions:
- Reduced quality of cardiovascular care before and after bereavement may elevate cardiovascular risk.
- Healthcare providers must ensure consistent, high-quality cardiovascular disease management for patients experiencing bereavement.
Background:
Bereavement is a period of increased risk of cardiovascular death. There is limited understanding of the potential contribution of quality of cardiovascular disease management to this increased risk.
Methods And Results:
In a UK primary-care database, 12 722 older individuals with preexisting cardiovascular disease (coronary heart disease, hypertension, diabetes mellitus, stroke) and a partner bereavement were matched with a non-bereaved control group (n=33 911). We examined key routine annual process measures of care in the year before and after bereavement and cardiovascular medication prescribing (lipid-lowering, antiplatelet, renin-angiotensin system drugs). Odds ratios for change after bereavement compared with the change in non-bereaved matched controls are presented. In the bereaved, uptake of all annual measures was lower in the year before bereavement, with improvement in the year after, whereas in the controls, uptake was relatively stable. The odds ratio for change was 1.30 (95% confidence interval, 1.15-1.46) for cholesterol measurement and 1.40 (95% confidence interval, 1.22-1.61) for blood pressure measurement. For all medication, there was a transient fall in prescribing in the peri-bereavement period lasting until about 3 months after bereavement. The odds ratio for at least 80% prescription coverage in the 30 days after bereavement was 0.80 (95% confidence interval, 0.73-0.88) for lipid-lowering medication and 0.82 (95% confidence interval, 0.74-0.91) for antiplatelet medication compared with the change in non-bereaved individuals.
Conclusions:
Lower uptake of key cardiovascular care measures in the year before bereavement and reduced medication coverage after bereavement may contribute to increased cardiovascular risk. Clinicians need to ensure that quality of cardiovascular care is maintained in the pre- and post-bereavement periods.
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