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Benign metastasizing leiomyoma presenting as cavitating lung nodules
Angeliki A Loukeri1, Ioannis N Pantazopoulos2, Rodoula Tringidou3
1Respiratory Intensive Care Unit angelouk@live.com.
Respiratory Care
|November 21, 2013
Summary
Benign metastasizing leiomyoma (BML) is a rare condition presenting as pulmonary nodules after uterine surgery. This case highlights successful diagnosis and management in a premenopausal woman with cavitating lung nodules.
Area of Science:
- Reproductive Medicine
- Pulmonary Pathology
- Surgical Oncology
Background:
- Benign metastasizing leiomyoma (BML) is characterized by smooth muscle cell proliferation in extrapelvic sites.
- Pulmonary involvement is common, necessitating differentiation from malignant lung neoplasms.
- Uterine leiomyoma and hysterectomy are key historical factors.
Observation:
- A 47-year-old premenopausal woman presented with bilateral cavitating pulmonary nodules.
- History of subtotal hysterectomy for uterine leiomyoma.
- Surgical resection of nodules via video-assisted thoracoscopic surgery.
Findings:
- Histopathological and immunohistochemical analysis confirmed BML.
- The resected nodules showed proliferating smooth muscle cells without atypia.
- Surgical management included bilateral salpingo-oophorectomy and cervical remnant removal.
Implications:
- This case demonstrates the diagnostic and therapeutic approach to BML.
- Hormonal suppression via oophorectomy may play a role in managing BML.
- Long-term stability of pulmonary nodules suggests effective treatment.
