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Myocardial infarction and histamine release

F Zaca, M S Benassi, M Ghinelli

    Agents and Actions
    |April 1, 1986
    PubMed

    Insights

    This study investigated plasma histamine (H) levels in patients with ischemic heart disease (IHD) and acute myocardial infarction (AMI). Elevated H levels correlated with creatine-kinase isoenzyme (CK-MB) trends during AMI, suggesting histamine’s potential role in heart disease.

    Area of Science:

    • Cardiology
    • Biochemistry
    • Pathophysiology

    Background:

    • Previous research suggests cardiac histamine involvement in ischemic heart disease (IHD).
    • Understanding histamine's role in acute myocardial infarction (AMI) is crucial for IHD management.

    Purpose of the Study:

    • To evaluate plasma histamine (H) and creatine-kinase isoenzyme (CK-MB) levels in patients with AMI, IHD, and healthy subjects.
    • To explore the correlation between plasma histamine and cardiac injury markers during AMI.

    Main Methods:

    • Plasma H and CK-MB levels were measured in 20 AMI patients, 10 IHD patients without AMI, and 10 healthy controls.
    • AMI patients included those who developed the condition in-hospital, allowing pre-event H level assessment.

    Main Results:

    • A positive correlation was observed between plasma H and CK-MB levels in 15 AMI patients, peaking 24 hours post-pain onset.
    • Seven IHD patients who later developed AMI exhibited higher pre-event plasma H levels compared to IHD patients who did not develop AMI.

    Conclusions:

    • Plasma histamine levels show a trend correlating with creatine-kinase isoenzyme during acute myocardial infarction.
    • Elevated plasma histamine prior to an acute event may indicate increased risk in ischemic heart disease patients.
    • Histamine may play a role in the pathogenesis of acute myocardial infarction.

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