Related Experiment Video
Updated: May 5, 2026
Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
Published on: March 10, 2020
[Study on the differences of risk factors regarding congenital heart defects between floating population and
Yan-qiu Ou1, Zhi-qiang Nie, Xiao-qing Liu
1Department of Cardiovascular Epidemiology, Guangdong Cardiovascular Institute, Guangdong General Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510080, China.
Insights
Risk factors for congenital heart defects (CHD) differ significantly between Guangdong's floating and permanent populations. Specific risks like passive smoking are more prevalent in the floating group, while factors like maternal diabetes are key in permanent residents.
Area of Science:
- Epidemiology
- Public Health
- Genetics
Context:
- Congenital heart defects (CHD) represent a significant global health concern.
- Guangdong province, China, presents a unique demographic landscape with both floating and permanent resident populations.
- Understanding population-specific risk factors is crucial for targeted public health interventions.
Purpose:
- To investigate and compare the distinct risk factors associated with congenital heart defects (CHD) in Guangdong's floating and permanent resident populations.
- To identify specific environmental, maternal, and socioeconomic factors influencing CHD occurrence in these two distinct groups.
Summary:
- A multicenter case-control study analyzed 855 CHD cases in the floating population and 1673 in permanent residents (2004-2011).
- Specific risk factors identified include maternal passive smoking (floating) and maternal diabetes/syphilis (permanent).
- Higher odds ratios for several risk factors were observed in the floating population compared to permanent residents.
Impact:
- Findings highlight the need for tailored prevention strategies for CHD based on population mobility and residency status.
- Identifies specific risk factors that can inform public health policies and clinical guidance in diverse populations.
- Contributes to a better understanding of environmental and socioeconomic influences on congenital heart defect (CHD) etiology.
Objective:
To analyze the differences of risk factors on congenital heart defect (CHD)between floating population and permanent residents in Guangdong.
Methods:
A multicenter case-control study was carried out to investigate the risk factors of CHD in floating population and in permanent residents. Data was from 34 Guangdong CHD Monitoring Network centers during the year of 2004 to 2011. Exposed information related to the parents at pre-pregnancy and early pregnancy periods, was collected, using the same questionnaire survey methodology in the two populations. Possible risk factors were analyzed by univariate analysis and multivariate non-conditional logistic regression(ENTER method)methods. Risk factors were compared between the two populations.
Results:
Totally, 855 CHD cases and their controls from the floating population, as well as 1673 cases and their controls from the permanent residents were included in this study. Age of the children under study was defined from 28th week of gestation to 1 year old postnatal. In the floating population, specific risk factor for CHD appeared as:maternal passive smoking in early pregnancy, while the specific protective factor as high family income. However, the specific risk factors would include: having diseases as maternal diabetes mellitus or syphilis, living in a newly (within half a year) decorated house or with fetal macrosomia in the permanent residents. High education level showed as a risk factor in floating population, however contrarily, as protective factor to the permanent residents. Except for the factors related to having fever of the mother and infant with low birth weight, factors as having history of deliveries more than two, with maternal virus infection, exposure to chemical agent and negative bearing history etc., have higher OR values in floating population than in the permanent residents.
Conclusion:
Significant differences of risk factors for CHD were noticed between floating population and the permanent residents, which have their individual specific risk factors. Most of the ORs appeared higher in floating population than in the permanent residents.
