Magnetic resonance imaging characterization of microbial infections
Verena Hoerr1, Cornelius Faber1
1Department of Clinical Radiology, University Hospital of Muenster, 48149 Muenster, Germany.
Abstract:
The investigation of microbial infections relies to a large part on animal models of infection, if host pathogen interactions or the host response are considered. Especially for the assessment of novel therapeutic agents, animal models are required. Non-invasive imaging methods to study such models have gained increasing importance over the recent years. In particular, magnetic resonance imaging (MRI) affords a variety of diagnostic options, and can be used for longitudinal studies. In this review, we introduce the most important MRI modalities that show how MRI has been used for the investigation of animal models of infection previously and how it may be applied in the future.
Insights
Magnetic resonance imaging (MRI) is crucial for studying animal infection models and evaluating new therapies. This review highlights MRI
Area of Science:
- Infectious diseases
- Medical imaging
- Animal models
Background:
- Animal models are essential for studying host-pathogen interactions and host responses in microbial infections.
- Assessing novel therapeutic agents necessitates the use of validated animal infection models.
- Non-invasive imaging techniques are increasingly vital for studying these models.
Purpose of the Study:
- To review the application of magnetic resonance imaging (MRI) in animal models of infection.
- To highlight the capabilities of various MRI modalities for infection research.
- To explore future applications of MRI in studying infectious diseases in animal models.
Main Methods:
- Review of existing literature on MRI applications in animal infection models.
- Discussion of different magnetic resonance imaging modalities.
- Analysis of past and potential future uses of MRI for infection investigation.
Main Results:
- Magnetic resonance imaging (MRI) offers diverse diagnostic options for infection studies.
- MRI enables longitudinal monitoring of disease progression and treatment response in animal models.
- Various MRI techniques have been successfully applied to investigate different types of infections in animals.
Conclusions:
- Magnetic resonance imaging (MRI) is a powerful non-invasive tool for advancing the study of microbial infections in animal models.
- Future applications of MRI hold significant promise for the development of new anti-infective therapies.
- The integration of MRI enhances our understanding of host-pathogen dynamics and therapeutic efficacy.
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