Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Quantitative CT-Based Analysis of Vertebral Rotational Asymmetry and Pulmonary Function in Scoliosis.

Journal of clinical medicine·2026
Same author

Comparison of multistage and single-stage framework for automated landmark localization and radiologic measurement: a case of the C1-2 complex on cervical spine lateral radiographs.

BMC medical imaging·2026
Same author

Identifying communal user needs for quality of experience (QoE) evaluation and improvement focused on user-centered design.

Acta psychologica·2025
Same author

Synergistic chemo-photothermal therapy and osteogenic activity using graphene oxide-functionalized composite whitlockite bone particles.

Journal of materials chemistry. B·2025
Same author

Evaluation of landscape created by erosion control dam using physiological and psychological indicators.

PloS one·2024
Same author

An Enhanced Tree Routing Based on Reinforcement Learning in Wireless Sensor Networks.

Sensors (Basel, Switzerland)·2023

Related Experiment Video

Updated: May 5, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

3.1K

A polycaprolactone/cuttlefish bone-derived hydroxyapatite composite porous scaffold for bone tissue engineering.

Beom-Su Kim1, Sun-Sik Yang, Jun Lee

  • 1Wonkwang Bone Regeneration Research Institute, Wonkwang University, Iksan, 570-749, Republic of Korea; Bonecell Biotech Inc., Dunsan-dong, Seo-gu, Daejeon, 302-830, Republic of Korea.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|November 22, 2013
PubMed
Summary

Cuttlefish bone-derived hydroxyapatite (CB-HAp) enhances polycaprolactone scaffolds, promoting new bone formation in rabbits. This composite shows promise for bone tissue engineering applications.

Keywords:
bone tissue engineeringcuttlefish bonehydroxyapatitepolycaprolactoneporous scaffold

More Related Videos

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.8K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.8K

Related Experiment Videos

Last Updated: May 5, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

3.1K
Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.8K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.8K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Materials Science

Background:

  • Cuttlefish bone (CB) is a natural source for hydroxyapatite (HAp).
  • Porous polycaprolactone (PCL) scaffolds are used in bone regeneration.
  • Combining CB-HAp with PCL may enhance scaffold properties.

Purpose of the Study:

  • To fabricate and characterize a PCL scaffold incorporating CB-derived HAp (CB-HAp).
  • To evaluate the in vitro cellular response and in vivo bone regeneration capacity of the PCL/CB-HAp scaffold.

Main Methods:

  • Solvent casting and particulate leaching method used for scaffold fabrication.
  • X-ray diffraction (XRD) and scanning electron microscopy (SEM) for material characterization.
  • In vitro cell assays (proliferation, cytotoxicity, attachment, alkaline phosphatase activity) and in vivo rabbit calvarial defect implantation.

Main Results:

  • PCL/CB-HAp scaffolds exhibited ~85% porosity with 200-300 μm pores and increased compressive modulus.
  • In vitro studies showed improved MG-63 cell proliferation, viability, adherence, and osteoblast differentiation.
  • In vivo implantation in rabbits demonstrated significantly higher new bone formation compared to PCL alone.

Conclusions:

  • The addition of CB-HAp to PCL scaffolds improves cellular responses and osteogenic differentiation.
  • The PCL/CB-HAp composite scaffold demonstrates significant potential for bone tissue engineering applications.