Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

27
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
27
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

918
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
918
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

35
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
35
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

572
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
572
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.2K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.2K
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

49
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
49

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Medication Burden: Beyond Counts to Recognize Polypharmacy as an Inherent Part of Living With Chronic Kidney Disease.

Basic & clinical pharmacology & toxicology·2026
Same author

Biological tapering is cost-effective in patients with inflammatory arthritis in the biosimilar era: secondary analyses on the randomised BIODOPT trial.

EULAR rheumatology open·2026
Same author

Evaluation of pan-alimentary MRI examinations: intrasubject variability and examination duration.

Abdominal radiology (New York)·2026
Same author

Multifactorial Machine Learning Algorithm Integration of Pain Mechanisms Can Predict the Efficacy of 3-Week NSAID Plus Paracetamol in Patients With Painful Knee Osteoarthritis.

European journal of pain (London, England)·2025
Same author

Person-centred medicine in the care home setting: feasibility testing of a complex intervention.

BMC primary care·2025
Same author

Strategy for Withdrawal of Pharmacological Treatment for Urinary Incontinence in Children (StayDry): Protocol for an Open-Label Prospective Randomized Trial.

JMIR research protocols·2025

Related Experiment Video

Updated: May 5, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

3.6K

Pharmacological challenges in chronic pancreatitis.

Anne Estrup Olesen1, Anne Brokjaer, Iben Wendelboe Fisher

  • 1Anne Estrup Olesen, Anne Brokjaer, Iben Wendelboe Fisher, Isabelle Myriam Larsen, Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, 9000 Aalborg, Denmark.

World Journal of Gastroenterology
|November 22, 2013
PubMed
Summary

Drug absorption is altered in chronic pancreatitis due to disease pathophysiology and lifestyle factors. This can impact medication effectiveness and explain varied patient responses to treatments.

Keywords:
AbsorptionChronic pancreatitisMetabolismPharmacologyTreatment

More Related Videos

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

646
Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

4.2K

Related Experiment Videos

Last Updated: May 5, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

3.6K
An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

646
Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

4.2K

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Internal Medicine

Background:

  • Chronic pancreatitis (CP) significantly alters gastrointestinal function, impacting drug absorption.
  • Disease-related factors include exocrine insufficiency, altered pH, motility issues, and bacterial overgrowth.
  • Patient lifestyle, including dietary changes and substance use (alcohol, tobacco), further modifies the gastrointestinal environment.

Purpose of the Study:

  • To explore how chronic pancreatitis pathophysiology affects drug absorption.
  • To identify key gastrointestinal changes in CP patients relevant to pharmacokinetics.
  • To understand the influence of lifestyle and common pain management strategies (opioids) on drug efficacy.

Main Methods:

  • Review of existing literature on chronic pancreatitis and drug absorption.
  • Analysis of pathophysiological mechanisms affecting the gastrointestinal tract in CP.
  • Examination of the pharmacokinetic implications of lifestyle factors and opioid use.

Main Results:

  • Exocrine pancreatic insufficiency leads to malabsorption and altered drug efficacy.
  • Gastrointestinal changes (pH, motility, bacterial flora) directly impact drug absorption.
  • Opioid use for pain management further modifies drug absorption via effects on motility and fluid absorption.

Conclusions:

  • Multiple factors in chronic pancreatitis, including disease processes and patient behaviors, significantly influence drug absorption and metabolism.
  • These influences can lead to inter-individual variability in drug response among CP patients.
  • Understanding these factors is crucial for optimizing pharmacological interventions in chronic pancreatitis management.