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Stability of captopril in SyrSpend SF
Christine M Geiger1, Bridget Sorenson, Paul A Whaley
1Dynalabs, LLC, St. Louis, Missouri, USA.
International Journal of Pharmaceutical Compounding
|November 23, 2013
Summary
Captopril suspensions in SyrSpend SF are stable for 14 days when refrigerated and protected from light. This provides an alternative dosage form for patients unable to swallow captopril tablets.
Area of Science:
- Pharmaceutical Sciences
- Drug Stability
- Compounding Pharmacy
Background:
- Captopril, an angiotensin-converting enzyme inhibitor, is typically administered as a tablet.
- Alternative dosage forms are needed for patients with difficulty swallowing tablets.
- Compounding pharmacies explore solutions and suspensions for captopril delivery.
Purpose of the Study:
- To evaluate the stability of captopril in a sorbitol-free, alcohol-free suspending agent.
- To determine the beyond-use date for compounded captopril suspensions.
Main Methods:
- Captopril was compounded into a 0.8-mg/mL suspension using SyrSpend SF.
- Samples were stored in low-actinic plastic bottles under refrigeration (2°C–8°C).
- Stability was assessed using a stability-indicating high-performance liquid chromatography method over 32 days.
Main Results:
- Captopril suspensions maintained 90%–110% of initial concentration through day 14.
- Stability data supports a 14-day beyond-use date under specified storage conditions.
Conclusions:
- Compounded captopril suspensions in SyrSpend SF are stable for 14 days when refrigerated and protected from light.
- This formulation offers a viable alternative dosage form for patients requiring captopril.
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