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Related Experiment Video

Updated: May 5, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
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Deep brain stimulation for Tourette syndrome.

Won Kim1, Nader Pouratian

  • 1Department of Neurosurgery, University of California, Los Angeles 10945, Le Conte Avenue, Suite 2120, Los Angeles, CA 90095, USA.

Neurosurgery Clinics of North America
|November 23, 2013
PubMed
Summary

Deep brain stimulation (DBS) offers a novel treatment for refractory Tourette syndrome, a movement disorder. Further multicenter trials are needed to confirm the efficacy of DBS for Tourette syndrome patients.

Keywords:
Deep brain stimulationNeuromodulationTicsTourette Syndrome

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Area of Science:

  • Neurology
  • Neurosurgery

Background:

  • Gilles de la Tourette syndrome is a complex movement disorder.
  • Characterized by repetitive motor and phonic tics.
  • Often accompanied by psychiatric comorbidities.

Purpose of the Study:

  • To review Deep Brain Stimulation (DBS) as a therapeutic intervention for refractory Tourette syndrome.
  • To assess the current status and future directions of DBS in Tourette syndrome management.

Main Methods:

  • Review of studies and clinical experience with DBS for Tourette syndrome since 1999.
  • Focus on targets within the corticostriatothalamocortical network.
  • Analysis of over 100 patient cases.

Main Results:

  • Deep brain stimulation (DBS) has been utilized in over 100 patients with Tourette syndrome.
  • Various targets within the corticostriatothalamocortical network have been explored.
  • DBS shows promise as a novel therapeutic approach for severe cases.

Conclusions:

  • Deep brain stimulation (DBS) is an emerging treatment for refractory Tourette syndrome.
  • Further multicenter clinical trials are essential.
  • A centralized database is recommended to standardize and compare results for definitive efficacy assessment.