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Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
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The relationship between leptin and ventilatory control in heart failure
Ivan Cundrle1, Virend K Somers, Prachi Singh
1International Clinical Research Center, Department of Anesthesiology and Intensive Care, St. Anna's University Hospital, Brno, Czech Republic; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
Journal of Cardiac Failure
|November 23, 2013
Summary
In heart failure (HF) patients, both high and low leptin levels are linked to abnormal breathing during exercise. This suggests leptin plays a complex role in how the body controls ventilation in HF.
Area of Science:
- Cardiology
- Pulmonology
- Endocrinology
Background:
- Elevated leptin is linked to increased ventilation in mild heart failure (HF).
- Conversely, leptin deficiency in animal models is also associated with increased ventilation.
- The precise relationship between leptin and ventilation in HF patients requires further investigation.
Purpose of the Study:
- To investigate the association between circulating leptin concentration and exercise ventilation in ambulatory heart failure (HF) patients.
Main Methods:
- Fifty-eight HF patients were categorized into quintiles based on serum leptin concentration.
- Exercise ventilation parameters, including ventilatory efficiency (VE/VCO2) and end-tidal carbon dioxide pressure (PETCO2), were measured.
- Multiple regression analysis was employed to assess the independent correlation between leptin levels and ventilation, adjusting for confounders.
Main Results:
- Peak exercise ventilatory efficiency (VE/VCO2) was significantly elevated in both the lowest and highest leptin concentration quintiles compared to the middle quintile.
- Leptin concentration showed an independent inverse correlation with VE/VCO2 in lower quintiles and a positive correlation in higher quintiles.
- Leptin concentration was positively correlated with PETCO2 in lower quintiles and inversely correlated in higher quintiles.
Conclusions:
- A nonlinear, U-shaped relationship exists between leptin concentration and ventilatory efficiency (VE/VCO2) in HF patients.
- Both high and low leptin concentrations are associated with increased VE/VCO2 and decreased PETCO2.
- These findings suggest that leptin deficiency or leptin resistance may significantly modulate ventilatory control in the context of heart failure.
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