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Related Experiment Video

Updated: May 5, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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VEGF targets the tumour cell.

Hira Lal Goel1, Arthur M Mercurio

  • 1Department of Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA.

Nature Reviews. Cancer
|November 23, 2013
PubMed
Summary

Vascular endothelial growth factor (VEGF) signaling in tumor cells drives tumorigenesis, impacting cancer stem cells and tumor initiation. Neuropilins are key mediators of VEGF effects on tumor cells, crucial for therapeutic development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Vascular endothelial growth factor (VEGF) is traditionally known for its roles in angiogenesis and vascular permeability.
  • VEGF signaling also plays a direct role within tumor cells, influencing key tumorigenesis processes.
  • Understanding these intracellular functions is critical for advancing cancer therapy.

Purpose of the Study:

  • To elucidate the non-angiogenic functions of VEGF signaling within tumor cells.
  • To investigate the role of neuropilins in mediating VEGF effects on tumor cell biology.
  • To explore the implications for novel therapeutic strategies in cancer treatment.

Main Methods:

  • Analysis of VEGF-mediated signaling pathways in tumor cells.
  • Investigation of neuropilin involvement in growth factor receptor and integrin regulation.

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  • Examination of VEGF's impact on cancer stem cell function and tumor initiation.

    • Main Results:

    • VEGF signaling directly contributes to tumorigenesis, including cancer stem cell function and tumor initiation.
    • Neuropilins are essential for mediating VEGF's effects on tumor cells.
    • Neuropilins regulate the function and trafficking of growth factor receptors and integrins.

    Conclusions:

    • VEGF's role in cancer extends beyond angiogenesis to direct tumor cell signaling.
    • Neuropilins are critical regulators of VEGF action in tumor cells.
    • Targeting neuropilin-mediated VEGF signaling offers potential for improved cancer therapeutics.