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Persistent aluminum accumulation after prolonged systemic aluminum exposure.
1College of Pharmacy and Graduate Center for Toxicology, University of Kentucky, 40536, Lexington, Kentucky.
Biological Trace Element Research
|November 23, 2013
Summary
This study shows that aluminum (A1) accumulates in rabbit tissues, especially the kidneys, liver, and bone, after repeated injections. These findings suggest that measuring A1 in these organs could help diagnose human A1 overload conditions.
Area of Science:
- Toxicology
- Biochemistry
- Animal Models
Background:
- Systemic aluminum (A1) exposure can lead to toxic effects.
- Understanding aluminum distribution is crucial for diagnosing A1 overload conditions.
Purpose of the Study:
- To investigate the distribution and accumulation of aluminum in various tissues following repeated systemic exposure in rabbits.
- To evaluate the rabbit as a model for studying aluminum intoxication syndromes.
Main Methods:
- Female New Zealand white rabbits received 20 subcutaneous injections of aluminum lactate at varying doses over 4 weeks.
- Tissues were analyzed for aluminum content using graphite furnace atomic absorption spectroscopy 5 weeks post-injection.
Main Results:
- Aluminum concentration increased in most tissues, including bone, heart, kidney, liver, lung, and spleen, correlating with exposure dose.
- Kidney cortex showed the highest accumulation (1290 μg/g) at the highest dose.
- Central nervous system regions showed a 53% increase in aluminum levels compared to controls.
Conclusions:
- Aluminum accumulates in rabbit tissues, with significant concentrations in the kidneys, liver, and bone.
- Measuring aluminum in kidney, liver, or bone may aid in diagnosing human aluminum overload disorders.
- The rabbit serves as a viable model for further research into aluminum intoxication.
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