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Correction: Hao et al. Enhanced Chemoprevention of Prostate Cancer by Combining Arctigenin with Green Tea and Quercetin in Prostate-Specific Phosphatase and Tensin Homolog Knockout Mice. <i>Biomolecules</i> 2024, <i>14</i>, 105.

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Updated: May 5, 2026

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
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T-cell LPD of the GIT: first do no harm.

Jonathan Said1

  • 1UNIVERSITY OF CALIFORNIA, LOS ANGELES.

Blood
|November 23, 2013
PubMed
Summary

This study identifies an indolent gastrointestinal T-cell lymphoproliferative disorder (LPD) that can mimic inflammatory bowel disease or peripheral T-cell lymphoma (PTCL). The disorder involves clonal T-cell receptor gene rearrangements.

Area of Science:

  • Gastroenterology
  • Hematology
  • Oncology

Background:

  • Gastrointestinal tract (GIT) lymphoproliferative disorders (LPDs) can present with diverse clinical and histological features.
  • Distinguishing indolent LPDs from inflammatory conditions or aggressive lymphomas is clinically significant.

Purpose of the Study:

  • To describe the clinicopathologic features of a series of indolent T-cell LPDs affecting the GIT.
  • To highlight the potential for misdiagnosis as inflammatory bowel disease or peripheral T-cell lymphoma (PTCL).

Main Methods:

  • Histopathological examination of GIT biopsy specimens.
  • Immunophenotypic analysis of lymphoid infiltrates.
  • T-cell receptor (TCR) gene rearrangement studies to assess clonality.

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Main Results:

  • Cases presented with lesions throughout the GIT, predominantly involving mucosal infiltrates of small lymphoid cells.
  • Immunophenotypically, the infiltrates were heterogeneous but predominantly CD8+/CD4-.
  • All cases demonstrated clonal TCR gene rearrangements, confirming a lymphoproliferative process.

Conclusions:

  • An indolent T-cell LPD of the GIT exists with features that can mimic inflammatory bowel disease or PTCL.
  • Accurate diagnosis relies on a combination of histology, immunophenotyping, and molecular analysis for TCR clonality.