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Serum omentin 1 level is associated with coronary artery disease and its severity in postmenopausal women

Imran Onur1, Fahrettin Oz2, Sezai Yildiz3

  • 1Department of Cardiology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.

Angiology
|November 23, 2013
PubMed

Insights

Lower serum omentin 1 levels are linked to coronary artery disease (CAD) and its severity in postmenopausal women. This finding suggests omentin 1 may be a predictor for cardiovascular risk in this demographic.

Area of Science:

  • Cardiology
  • Endocrinology
  • Women's Health

Background:

  • Coronary artery disease (CAD) is a significant health concern in postmenopausal women.
  • Adipokines, such as omentin, may play a role in cardiovascular health.
  • The association between serum omentin levels and CAD in postmenopausal women requires further investigation.

Purpose of the Study:

  • To investigate the relationship between serum omentin 1 levels and the presence and severity of coronary artery disease (CAD) in postmenopausal women.

Main Methods:

  • A cohort of 193 postmenopausal women undergoing coronary angiography was studied.
  • Participants were categorized into a CAD group (n=110) and a control group (n=83).
  • Serum omentin 1 levels were measured, and CAD severity was assessed using the SYNTAX score (SS).

Main Results:

  • Postmenopausal women with angiographic CAD exhibited significantly lower serum omentin 1 levels compared to controls (247.5±127.4 vs 506±246 ng/mL, P<.001).
  • Decreased omentin 1 levels were identified as an independent predictor of both angiographic CAD and high SYNTAX scores, even after adjusting for cardiovascular risk factors.

Conclusions:

  • Serum omentin 1 levels are significantly associated with the presence of coronary artery disease (CAD) in postmenopausal women.
  • Lower omentin 1 levels are indicative of increased CAD severity, as measured by the SYNTAX score.
  • Omentin 1 may serve as a potential biomarker for predicting CAD and its severity in postmenopausal women.

Keywords:
adipose tissuecoronary artery diseaseinflammationomentin 1postmenopausal womensyntax score

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