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Updated: May 5, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Synthesis of isoxazolin-5-one glucosides by a cascade reaction
Tobias Becker1, Helmar Görls, Gerhard Pauls
1Max Planck Institute for Chemical Ecology , Beutenberg Campus, Hans-Knoell-Straße 8, D-07745 Jena, Germany.
Abstract:
A novel synthetic route was developed for the construction of isoxazolin-5-one glucosides using a cascade reaction. An X-ray crystal structure analysis of a isoxazolin-5-one glucoside confirmed the structure and stereochemistry of the heterocycle. The properties of the α- and β-anomers of the isoxazolin-5-one glucosides were compared. The first synthesis of 2-[6'-(3″-nitropropanoyl)-β-D-glucopyranosyl]-3-isoxazolin-5-one was realized by direct enzymatic esterification without need of further protective groups.
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