Holter-monitored heart rhythm during atrioventricular synchronous and fixed-rate ventricular pacing

The purpose of this investigation was to study rate variability during normal everyday activities among physiologically paced patients. A comparison of the spontaneous occurrence of arrhythmias with ventricular inhibited pacing was also made. VDD pacemakers in 44 patients were randomly programmed to three-week long periods of VVI (70 bpm) or VDD (back-up rate 40-50 bpm, upper rate 125-150 bpm) pacing, respectively. A Holter ECG was recorded during the last 24 hours of each period. Although the total number of QRS complexes was similar in the two pacing modes (4.3 X 10(6)/24 hours), the rate span was extensively utilized during VDD pacing. During VDD pacing, only five patients of 39 with a programmed upper rate of 150 bpm reached this limit, while one of five with 125 bpm reached that rate. Occasional episodes of pacing at the back-up rate of 40 or 50 bpm were recorded in 33 patients. Episodes of asymptomatic rhythm disturbances were recorded in both pacing modes. No significant differences existed as regards ventricular tachyarrhythmias between the two modes of pacing and it did not seem that the incidence was higher than could be expected in a patient population of the present age. Since severe AV block does not permit conduction of atrial impulses during VVI pacing, no direct comparison between the two pacing modes can be made concerning atrial tachyarrhythmias. Only one episode of pacemaker-mediated SVT was found, and this was unsymptomatic.