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Total synthesis of human galanin-like peptide through an aspartic acid ligation
Xiaoyang Guan1, Matthew R Drake, Zhongping Tan
1Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado , Boulder, Colorado 80303, United States.
Organic Letters
|November 26, 2013
Abstract:
Human galanin-like peptide (hGALP) is a newly discovered hypothalamic peptide that plays important roles in the regulation of food intake and energy balance. Here, we demonstrate that the aspartic acid ligation can be employed to achieve an efficient synthesis of hGALP. The total synthesis of hGALP enhances our ability to study its biology and facilitates the development of more stable analogues.
