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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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Microscopic colitis.

Darrell S Pardi1

  • 1Division of Gastroenterology and Hepatology, Inflammatory Bowel Disease Clinic, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

Clinics in Geriatric Medicine
|November 26, 2013
PubMed
Summary
This summary is machine-generated.

Microscopic colitis causes chronic watery diarrhea, particularly in older adults. Diagnosis relies on histology, with budesonide being the most studied treatment option.

Keywords:
Collagenous colitisLymphocytic colitisMicroscopic colitis

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Area of Science:

  • Gastroenterology
  • Colorectal Diseases

Background:

  • Microscopic colitis is a significant cause of chronic watery diarrhea, predominantly affecting the elderly.
  • Associated symptoms include abdominal pain, arthralgias, and weight loss.
  • While incidence was rising, recent data suggest stabilization.

Purpose of the Study:

  • To summarize the epidemiology, diagnosis, and treatment of microscopic colitis.
  • To highlight the role of budesonide in randomized clinical trials.

Main Methods:

  • Diagnosis is confirmed through characteristic histologic findings on colonic biopsies.
  • Review of existing literature on microscopic colitis incidence, symptoms, and therapeutic options.

Main Results:

  • Microscopic colitis affects all ages but is most prevalent in the elderly.
  • Budesonide is the only treatment option extensively evaluated in randomized clinical trials.

Conclusions:

  • Microscopic colitis requires histological confirmation for diagnosis.
  • Budesonide demonstrates efficacy and is the most rigorously studied treatment for this condition.