Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

223
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
223
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.4K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

3.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.8K
Hypersensitivities01:30

Hypersensitivities

7.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.3K
Autoimmune Disorders01:29

Autoimmune Disorders

2.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.4K
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

286
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
286

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

γδ T cell localization and abundance in canine atopic dermatitis: An RNA in situ hybridization study.

Veterinary immunology and immunopathology·2026
Same author

Clinical, Histopathological and Epidemiological Features of Dorsal Melanotrichia of Poodles and Poodle Crosses.

Veterinary dermatology·2026
Same author

Effect of ear cleaning on treatment outcome for canine otitis externa.

Veterinary dermatology·2024
Same author

Burkholderia gladioli deep pyoderma in a dog secondary to immunosuppressive ciclosporin and prednisone therapy.

Veterinary dermatology·2024
Same author

Oclacitinib 10 years later: lessons learned and directions for the future.

Journal of the American Veterinary Medical Association·2023
Same author

Pathology in Practice.

Journal of the American Veterinary Medical Association·2022
Same journal

Pharmaceutical and Nutraceutical Therapies for Liver Disease.

The Veterinary clinics of North America. Equine practice·2026
Same journal

Clinical Signs of Liver Disease in Horses.

The Veterinary clinics of North America. Equine practice·2026
Same journal

Syndrome of High Gamma-Glutamyl Transferase in Racehorses.

The Veterinary clinics of North America. Equine practice·2026
Same journal

Equine Hepatology in Practice: Insights, Challenges, and Progress.

The Veterinary clinics of North America. Equine practice·2026
Same journal

Pathophysiology and Treatment of Hepatic Encephalopathy.

The Veterinary clinics of North America. Equine practice·2026
Same journal

Viral Hepatitis.

The Veterinary clinics of North America. Equine practice·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

9.9K

Immune-mediated dermatoses.

Wayne Rosenkrantz1

  • 1Animal Dermatology Clinic, 2965 Edinger Avenue, Tustin, CA 92780, USA.

The Veterinary Clinics of North America. Equine Practice
|November 26, 2013
PubMed
Summary
This summary is machine-generated.

This study reviews autoimmune skin diseases in horses, focusing on pemphigus foliaceus as the most common. It also discusses other rare conditions like pemphigus vulgaris, lupus erythematosus, and bullous pemphigoid.

Keywords:
AutoimmuneBullous pemphigoidErythema multiformeImmune mediatedLupus erythematosusPemphigusPurpura hemorrhagica

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

23.9K
Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

1.1K

Related Experiment Videos

Last Updated: May 5, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

9.9K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

23.9K
Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

1.1K

Area of Science:

  • Veterinary Dermatology
  • Immunology
  • Equine Health

Background:

  • Autoimmune skin diseases are recognized in horses.
  • Pemphigus foliaceus is the most prevalent, involving autoantibodies against keratinocyte surface proteins.
  • Other autoimmune conditions like pemphigus vulgaris, lupus erythematosus, and bullous pemphigoid are rare in horses.

Purpose of the Study:

  • To provide an overview of autoimmune skin diseases in horses.
  • To highlight the characteristics of pemphigus foliaceus.
  • To differentiate pemphigus foliaceus from other autoimmune skin conditions in equines.

Main Methods:

  • Literature review of equine autoimmune skin diseases.
  • Analysis of clinical and pathological features.
  • Comparison of disease prevalence and mechanisms.

Main Results:

  • Pemphigus foliaceus is the most common equine autoimmune skin disease.
  • Autoantibodies targeting keratinocyte surface proteins are key in pemphigus foliaceus.
  • Pemphigus vulgaris, lupus erythematosus, and bullous pemphigoid are rare equine autoimmune skin diseases.

Conclusions:

  • Understanding the spectrum of autoimmune skin diseases in horses is crucial for diagnosis and management.
  • Pemphigus foliaceus represents a significant autoimmune dermatopathy in the equine population.
  • Further research into the specific mechanisms and treatments for these conditions is warranted.