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Updated: May 5, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Papillomavirus-associated diseases
Sheila M F Torres1, Sandra N Koch
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Veterinary Medical Center, University of Minnesota, C339, 1352 Boyd Avenue, St. Paul, MN 55108, USA.
Abstract:
This article reviews various aspects of 3 clinical disorders associated with papillomavirus in horses commonly known as classical viral papillomatosis, genital papillomas/papillomatosis, and aural plaques. Classical papillomatosis is usually asymptomatic and spontaneously resolves within 1 to 9 months; therefore, treatment is often not required. Genital papillomas/papillomatosis have not been reported to spontaneously resolve, and there is increasing evidence that genital papillomas may evolve to in situ or invasive squamous cell carcinomas. Horses with aural plaques may be asymptomatic or may present with signs of ear and head hypersensitivity.
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