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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

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Published on: March 11, 2014

Papillomavirus-associated diseases.

Sheila M F Torres¹, Sandra N Koch

¹Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Veterinary Medical Center, University of Minnesota, C339, 1352 Boyd Avenue, St. Paul, MN 55108, USA.

The Veterinary Clinics of North America. Equine Practice

|November 26, 2013

Summary

This summary is machine-generated.

This review covers equine papillomavirus infections, including classical viral papillomatosis, genital papillomas, and aural plaques. While classical papillomas often resolve without treatment, genital forms may progress to cancer.

Keywords:

Aural Equine Horse Imiquimod Papilloma Papillomatosis Papillomavirus Viral

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Area of Science:

Veterinary Dermatology
Equine Medicine
Virology

Background:

Equine papillomaviruses cause distinct clinical conditions in horses.
Understanding these conditions is crucial for diagnosis and management.
Papillomavirus infections can impact horse health and well-being.

Purpose of the Study:

To review the clinical aspects of three equine papillomavirus-associated disorders.
To differentiate the natural history and potential sequelae of each condition.
To inform veterinary practitioners on diagnosis and treatment considerations.

Main Methods:

Literature review of clinical presentations and outcomes.
Analysis of spontaneous resolution rates and treatment requirements.
Evaluation of potential malignant transformation risks.

Main Results:

Classical viral papillomatosis typically resolves spontaneously within 1-9 months.
Genital papillomas/papillomatosis show no reported spontaneous resolution and may develop into squamous cell carcinoma.
Aural plaques can cause hypersensitivity, though some horses remain asymptomatic.

Conclusions:

Management strategies for equine papillomavirus depend on the specific clinical presentation.
Genital papillomas warrant close monitoring due to malignant potential.
Further research into treatment and prevention of equine papillomavirus is needed.