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Somatic growth and lung function in sickle cell disease
Tina Catanzaro1, Anastassios C Koumbourlis1
1Division of Pulmonary & Sleep Medicine, Children's National Medical Center/ George Washington University, School of Medicine, Washington DC, USA.
Paediatric Respiratory Reviews
|November 26, 2013
Summary
Somatic growth in sickle cell disease (SCD) varies, with some patients experiencing delayed growth while others maintain normal or increased stature. The link between growth and lung function in SCD requires further investigation.
Area of Science:
- Pediatrics
- Hematology
- Pulmonology
Background:
- Somatic growth is crucial for health and prognosis in chronic diseases.
- Sickle cell disease (SCD) is often associated with growth delays, but recent findings show varied growth patterns, including normal weight and obesity.
- The relationship between somatic growth and lung function in SCD is not fully understood.
Purpose of the Study:
- To review current knowledge on somatic growth in SCD.
- To explore the relationship between somatic growth and lung function in SCD.
- To discuss controversies and the role of micronutrients in SCD growth and lung function.
Main Methods:
- Literature review of studies on somatic growth in children and adults with SCD.
- Analysis of factors influencing growth, including malnutrition, socioeconomic status, and thoracic structural changes.
- Examination of the impact of diet and micronutrients on growth and lung function.
Main Results:
- Worldwide studies indicate predominantly delayed growth in SCD, particularly weight.
- Recent data reveal a spectrum of growth outcomes, with some patients exhibiting normal weight gain or obesity.
- Lung volumes are generally lower in SCD patients, irrespective of body weight, with potential contributions from thoracic structural changes.
Conclusions:
- Somatic growth in SCD is complex and variable, not universally delayed.
- Thoracic structural changes may impact lung growth in SCD.
- Optimal dietary interventions for improving growth and lung function in SCD remain unclear, warranting further research into micronutrient roles.
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