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Essential thrombocythemia as a risk factor for stillbirth
Takeshi Umazume1, Takahiro Yamada1, Rina Akaishi1
1Department of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, 060-8638, Japan.
Thrombosis Research
|November 26, 2013
Summary
Women with essential thrombocythemia (ET) face a high risk of stillbirth. Intensified fetal monitoring during pregnancy is crucial for improving outcomes in these high-risk pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Maternal-Fetal Medicine
Background:
- Essential thrombocythemia (ET) is associated with a known high risk of abortion.
- Limited research exists on stillbirth risk in ET pregnancies reaching viable gestational ages.
Purpose of the Study:
- To evaluate the risk of stillbirth in pregnancies complicated by essential thrombocythemia (ET).
- To compare stillbirth rates in ET pregnancies with national statistics.
Main Methods:
- Retrospective review of ET pregnancies at a single center (2003-2013).
- Literature review of studies reporting >20 ET pregnancies.
- Analysis of pregnancy outcomes: abortion, stillbirth (≥24 weeks), live birth (LB).
- Comparison with Japanese national stillbirth statistics (≥22 weeks).
Main Results:
- In nine ET pregnancies at the center: 2 miscarriages, 1 stillbirth (35 weeks), 6 live births.
- Literature review (374 outcomes): 29% miscarriage, 3.7% stillbirth (5.3% for ≥24 weeks), 67% live birth.
- National data: stillbirth risk <0.50% for ≥22 weeks.
Conclusions:
- The stillbirth risk in essential thrombocythemia pregnancies is exceptionally high.
- Enhanced fetal surveillance is recommended for pregnancies with ET to improve outcomes.
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