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Author Spotlight: Multiplex Immunohistochemistry for Understanding Immune Regulation by Uterine NK Cells in Pregnancy
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Recurrent implantation failure: definition and management.

C Coughlan1, W Ledger2, Q Wang3

  • 1Department of Reproductive and Developmental Medicine, Jessop Wing, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Reproductive Biomedicine Online
|November 26, 2013
PubMed
Summary
This summary is machine-generated.

Recurrent implantation failure (RIF) occurs after multiple embryo transfers. Investigations for RIF focus on identifying embryo, ovarian, or uterine factors to guide evidence-based treatment for improved pregnancy success.

Keywords:
IVFembryofailurefibroidshysterosalpingogramimplantation

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Area of Science:

  • Reproductive Medicine
  • Infertility Research
  • Embryology

Background:

  • Recurrent implantation failure (RIF) is defined as the inability to achieve pregnancy after multiple in vitro fertilization (IVF) cycles.
  • RIF can stem from various factors, including issues with embryo quality or uterine receptivity.

Purpose of the Study:

  • To outline comprehensive diagnostic approaches for recurrent implantation failure.
  • To emphasize the importance of identifying underlying causes for RIF.
  • To discuss evidence-based treatment strategies and alternative options.

Main Methods:

  • Assessment of ovarian reserve through antral follicle count, FSH, and anti-Müllerian hormone.
  • Exclusion of uterine pathologies via ultrasonography, hysteroscopy, and hysterosalpingogram.
  • Evaluation of sperm DNA fragmentation and exclusion of hydrosalpinges.

Main Results:

  • Thorough investigation can reveal specific causes of RIF, such as uterine abnormalities or hormonal imbalances.
  • Sperm DNA fragmentation and hydrosalpinges are identified as potential contributing factors.
  • Identifying the cause allows for targeted, evidence-based interventions.

Conclusions:

  • A systematic diagnostic workup is crucial for managing recurrent implantation failure.
  • Treatment should focus on optimizing embryo quality and endometrial receptivity.
  • Gamete donation or surrogacy may be considered when other options are exhausted.