Related Experiment Video
Updated: May 5, 2026

Merkel Cell Polyomavirus Infection and Detection
Published on: February 7, 2019
Mikulicz's disease. A case report
I Coloma-González1, L Ruíz-García1, J Flores-Preciado1
1Departamento de Órbita, Párpados y Vías Lagrimales, Hospital Dr. Luis Sánchez Bulnes, Asociación para Evitar la Ceguera IAP, México DF, México.
Case Report:
We report the case of a 48 year-old male with bilateral involvement of the salivary and lacrimal glands, which was diagnosed as Mikulicz's disease by incisional biopsy of the affected lacrimal glands, which was completely resolved after corticosteroid treatment.
Discussion:
Sclerosing sialadenitis and/or dacryoadenitis are chronic inflammatory diseases that are currently classified into IgG4-related diseases. Specifically, Mikulicz's disease is defined by a persistent and symmetrical swelling of the lacrimal and salivary glands together with elevated serum concentration of IgG4 and tissue infiltration by IgG4 (+) plasma cells.

