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Merkel Cell Polyomavirus Infection and Detection

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Mikulicz's disease. A case report.

I Coloma-González¹, L Ruíz-García¹, J Flores-Preciado¹

¹Departamento de Órbita, Párpados y Vías Lagrimales, Hospital Dr. Luis Sánchez Bulnes, Asociación para Evitar la Ceguera IAP, México DF, México.

Archivos De La Sociedad Espanola De Oftalmologia

|November 26, 2013

Summary

This summary is machine-generated.

Mikulicz

Keywords:

Dacrioadenitis Dacryoadenitis Enfermedad asociada a IgG(4)Enfermedad de Mikulicz Enfermedad inflamatoria de la órbita IgG4-related disease Inflammatory orbital disease Mikulicz's disease

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Area of Science:

Ophthalmology
Rheumatology
Pathology

Background:

Mikulicz's disease is a chronic inflammatory condition affecting salivary and lacrimal glands.
It is increasingly classified under IgG4-related diseases.
Diagnosis involves characteristic gland swelling and specific serological/histopathological findings.

Observation:

A 48-year-old male presented with bilateral salivary and lacrimal gland involvement.
Incisional biopsy of the lacrimal glands confirmed the diagnosis.
The patient experienced complete resolution following corticosteroid therapy.

Findings:

Mikulicz's disease presents as persistent, symmetrical swelling of lacrimal and salivary glands.
Elevated serum IgG4 concentrations and tissue infiltration by IgG4-positive plasma cells are key diagnostic markers.
This case highlights the efficacy of corticosteroids in managing the condition.

Implications:

This case underscores the importance of recognizing Mikulicz's disease as an IgG4-related condition.
Prompt diagnosis and treatment, such as corticosteroid therapy, can lead to favorable outcomes.
Further research into IgG4-related dacryoadenitis and sialadenitis is warranted.